Postdoctoral Researcher, Rzhetsky Lab, University of Chicago
Rachel Melamed is a postdoctoral research scientist in the laboratory of Raul Rabadan. Her undergraduate concentration was in computer science at Brown University. After a stint in software engineering, Rachel worked as a research assistant at the Benoist-Mathis Lab at Harvard Medical School, where she analyzed microarray data to understand mechanisms of T-cell activation as well as to compare mouse models of autoimmune disease. She has also worked on understanding cell signaling in immune cell types, and in immune-derived cancer cells, using many-dimensional single cell cytometric measurements. Her current work in the Rabadan Lab is focused on gene copy number and its influence on cancer development.
Connections Found between Mendelian Diseases and Cancer
Using electronic health records representing over 110 million patients, investigators in the Rabadan Lab show that comorbidity of Mendelian diseases and canver can be tied to genetic changes seen in both diseases.
MA, MPhil, PhD, Columbia University, Biomedical Informatics
BA, Brown University, Computer Science
Melamed RD, Emmett KJ, Madubata C, Rzhetsky A, Rabadan R. Genetic similarity between cancers and comorbid Mendelian diseases identifies candidate driver genes. Nat Commun. 2015 Apr 30.
Aydin IT, Melamed RD, Adams SJ, Castillo-Martin M, Demir A, Bryk D, Brunner G, Cordon-Cardo C, Osman I, Rabadan R, Celebi JT. FBXW7 mutations in melanoma and a new therapeutic paradigm. J Natl Cancer Inst. 2014 May 16;106(6):dju107.
Blair DR, Lyttle CS, Mortensen JM, Bearden CF, Jensen ABoeck, Khiabanian H, Melamed R, Rabadan R, Bernstam EV, Brunak S et al. 2013. A nondegenerate code of deleterious variants in Mendelian loci contributes to complex disease risk. Cell. 155(1):70-80.
Yang Y, Wu J, Demir A, Castillo-Martin M, Melamed RD, Zhang G, Fukunaga-Kanabis M, Perez-Lorenzo R, Zheng B, Silvers DN, Brunner G, Wang S, Rabadan R, Cordon-Cardo C, Celebi JT. GAB2 induces tumor angiogenesis in NRAS-driven melanoma. Oncogene. 2013 Aug 1;32(31):3627-37.
Aydin IT, Melamed RD, Adams SJ, Castillo-Martin M, Demir A, Bryk D, Brunner G, Cordon-Cardo C, Osman I, Rabadan R, Celebi JT. FBXW7 mutations in melanoma and a new therpeutic paradigm. J Natl Cancer Inst. 2014 May 16;106(6).
Bendall S, Simonds EF, Qui P, Amir ED, Krutzik PO, Finck R, Bruggner R, Melamed R, Ornatsky O, Balderas R, Plevritis S, Sachs K, Pe’er D, Tanner S, Nolan G. Single-cell mass cytometry of differential immune and drug responses across a human hematopoietic continuum. Science. 6 May 2011.
Venanzi ES, Melamed R, Mathis D, Benoist C. The variable immunological self: genetic variation and nongenetic noise in Aire-regulated transcription. Proc Natl Acad Sci U S A. 2008 Oct 14;105(41).
Hill JA, Feuerer M, Tash K, Haxhinasto S, Perez J, Melamed R, Mathis D, Benoist C. Foxp3 transcription-factor-dependent and -independent regulation of the regulatory T cell transcriptional signature. Immunity. 2007 Nov;27(5):786-800.
Obst R, van Santen HM, Melamed R, Kamphorst AO, Benoist C, Mathis D. Sustained antigen presentation can promote an immunogenic T cell response, like dendritic cell activation. Proc Natl Acad Sci U S A. 2007 Sep 25;104(39).
Hyatt G, Melamed R, Park R, Seguritan R, Laplace C, Poirot L, Zucchelli S, Obst R, Matos M, Venanzi E, Goldrath A, Nguyen L, Luckey J, Yamagata T, Herman A, Jacobs J, Mathis D, Benoist C. Gene expression microarrays: glimpses of the immunological genome. Nat Immunol. 2006 Jul;7(7):686-91.