Sebastien Weyn

Sebastien Weyn


Staff Associate

I am an Integrated Program PhD student in the laboratory of Chaolin Zhang. My work focuses on elucidating protein-RNA regulation networks on a transcriptome-wide scale, with a current emphasis on the regulation of alternative splicing during development. Some of the key players in this regulation are RNA-binding proteins (RBPs), which are able to create splicing programs that are specific to cell types and developmental time points. My goals are to identify the regulatory targets of these RBPs and determine how the RBPs work together to define specific splicing programs.
I received my BS in in the biochemistry honors program at the University of Texas at Austin. While there, I worked with Igor Ponomarev and Adron Harris to investigate the genetic changes in the brain following alcohol exposure.

Education History

BS, University of Texas at Austin
Biochemistry Honors


* indicates equal author contributions

Shah A, Qian Y, Weyn-Vanhentenryck SM, Zhang C. CLIP Tool Kit (CTK): a flexible and robust pipeline to analyze CLIP sequencing data. Bioinformatics. 2016 Oct 22. 

Yan Q*, Weyn-Vanhentenryck SM*, Wu J, Sloan SA, Zhang Y, Chen K, Wu JQ, Barres BA, Zhang C. Systematic discovery of regulated and conserved alternative exons in the mammalian brain reveals NMD modulating chromatin regulators. Proc Natl Acad Sci U S A. 2015 Mar 3. 

Weyn-Vanhentenryck SM*, Mele A*, Yan Q*, Sun S, Farny N, Zhang Z, Xue C, Silver PA, Zhang MQ, Krainer AR, Darnell RB, Zhang C. HITS-CLIP and integrative modeling define the Rbfox splicing-regulatory network linked to brain development and autism. Cell Rep. 2014 Mar 27;6(6):1139-52.