Vilde Leipart

Titles

Adjunct postdoc

Vilde Leipart is a postdoctoral researcher at the Norwegian University of Life Sciences (NMBU) and is currently hosted by the Honig Lab. She earned her Ph.D. from NMBU in 2022, titled “Understanding the structure–function relationship of honey bee Vitellogenin”. Her doctoral work combined computational and experimental approaches to study protein structure-function relationships, focusing on Vitellogenin (Vg) in honey bees. She contributed to the structural characterization of Vg, including the first full-length structure prediction, the zinc-binding, and analyses of naturally occurring protein variants in honey bee subspecies. As part of her postdoctoral work, she conducted research with the Orengo and Fraternali labs at University College London before joining the Honig Lab. Her current work uses protein structure prediction and bioinformatics to study protein-ligand interactions with Vg ligands, such as lipids and DNA, and to predict protein-protein interactions across insect proteomes.


Education History

PhD, Norwegian University of Life Sciences (NMBU), Ecology and Natural Resource Management

MSc, Norwegian University of Science and Technology (NTNU), Molecular Medicine

BSc, University of Oslo (UiO), Molecular Biology and Biological Chemistry


Publications

Leipart V, Montserrat-Canals M, et al. Structure prediction of honey bee vitellogenin: a multi-domain protein important for insect immunity. FEBS Open Bio, 2022, 12: 51-70

Leipart V, Ludvigsen J, Kent M, Sandve S, et al. Identification of 121 variants of honey bee Vitellogenin protein sequences with structural differences at functional sites. Protein Science, 2022;31(7):e4369

Leipart V, Enger Ø, et al. Resolving the zinc binding capacity of honey bee vitellogenin and locating its putative binding sites. Insect Molecular Biology, 31(6), 810–820

Leipart V, Halskau Ø, Amdam GV. How Honey Bee Vitellogenin Holds Lipid Cargo: A Role for the C-Terminal. Front. Mol. Biosci. 2022 9:865194

Rocque MJ, Leipart V, Singh AK, et al. Characterization of POLE c.1373A > T p.(Tyr458Phe), causing high cancer risk. Mol Genet Genomics 298, 555–566, 2023

Montserrat-Canals M, Schnelle K, Leipart V, et al. Cryo-EM structure of native honey bee vitellogenin. Nature Communications. Nat Commun 16, 5736 (2025)

Leipart V, Carmona OG, et al. Assessing structure-function impacts on Vitellogenin by leveraging allelic variant occurring in honey bee subspecies Apis mellifera mellifera. iScience, 2025; 28

Harwood G, Leipart V, et al. Evidence for Vitellogenin DNA-binding in honey bees. Protein Science. Protein Science. 2025;34(10):e70291

Carmona OG, Leipart V, et al. Leveraging protein language models and scoring function for Indel characterisation and transfer learning. Patterns, 2025; 7