Ye Wang

Titles

Postdoctoral Research Scientist

Prior to joining Zhang lab, Ye obtained her PhD training on computational and synthetic biology in Tsinghua university. During her PhD, she proposed an AI-based generative framework for the de novo design of promoter elements in Escherichia coli, which showed a high success rate based on experimental validation in vivo. For her postdoc research, she plans to focus on inverse design of synthetic exons/introns to understand splicing regulation and their function in brain and developmental disorders, with an ultimate goal to facilitate the development of RNA-based precision genetic medicine. Outside the lab, Ye is passionate about yoga, running, and cooking.


Education History

 PhD, Tsinghua National Laboratory for Information Science and Technology, Department of Automation, Tsinghua University, Beijing, China.


Publications

Zhang P, Du Q, Wang Y, Wei L, Wang X. Systematic representation and optimization enable the inverse design of cross-species regulatory sequences in bacteria. Nat Commun. 2025 Feb 19;16(1):1763. 

Xu C, Bao S, Wang Y, Li W, Chen H, Shen Y, Jiang T, Zhang C. Reference-informed prediction of alternative splicing and splicing-altering mutations from sequences. Genome Res. 2024 Aug 20;34(7):1052-1065.