Rare cell analysis of therapy resistance in cancer

Dr. Arjun Raj
University of Pennslylvania

Irving Cancer Research Center
1130 St. Nicholas Avenue
Room 816
New York, NY 10032


Therapies targeting mutated proteins hold much promise in the treatment of cancer, but the emergence of resistance to these therapies presents a major barrier to cures. Recent work, including some results from our lab in melanoma, shows that non-genetic cellular plasticity may provide a mechanism of resistance to these therapies. Furthermore, the addition of the drug itself converts this transient plasticity into a new, stably resistant cell state via cellular reprogramming. We further describe a genome-wide method of identifying high-memory rare-cell expression programs that are phenotypically distinct.

Event Series Name
Department of Systems Biology Distinguished Seminar Series
Peter Sims

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11-08-17 03:00:00
11-08-17 04:00:00
ICRC 8th Floor Room 816