November 8, 2017 - 3:00pm
Rare cell analysis of therapy resistance in cancer
Therapies targeting mutated proteins hold much promise in the treatment of cancer, but the emergence of resistance to these therapies presents a major barrier to cures. Recent work, including some results from our lab in melanoma, shows that non-genetic cellular plasticity may provide a mechanism of resistance to these therapies. Furthermore, the addition of the drug itself converts this transient plasticity into a new, stably resistant cell state via cellular reprogramming. We further describe a genome-wide method of identifying high-memory rare-cell expression programs that are phenotypically distinct.
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