This meeting of the Department of Systems Biology journal club will feature a discussion of 3 papers relevant to Haiyuan Yu's seminar on November 19, "Understanding Molecular Mechanisms of Human Disease Mutations and Coding Variants through 3D Protein Networks"

Discussion will focus on the following papers:

Three-dimensional reconstruction of protein networks provides insight into human genetic disease, by Wang et al 2012, Nature Biotechnology. 

Dissecting disease inheritance modes in a three-fimensional protein network challenges the “guilt-by-association” principle, by Guo et al 2013, ASHG.

Cross-species protein interactome mapping reveals species-specific wiring of stress response pathways, by Das et al 2013, Sci. Signal.