Brent Stockwell

Brent Stockwell


Professor, Departments of Biological Sciences and Chemistry
Director, Chemical Probe Synthesis Facility
Co-director, High-Throughput Screening, Columbia Genome Center
Early Career Scientist, Howard Hughes Medical Institute


JP Sulzberger Columbia Genome Center
Department of Biological Sciences
Department of Chemistry
Center for Motor Neuron Biology and Disease


(212) 854-2899

Brent Stockwell is an associate professor in the Departments of Biological Sciences and Chemistry. He is also a Howard Hughes Medical Institute Investigator. His research group, which works at the interface of chemistry and biology, uses small organic molecules in a systematic way to perturb cellular processes and discover their underlying mechanisms. Stockwell’s approach is interdisciplinary, combining chemical design and synthesis with genomics, computational chemistry, biochemistry, and cell biology, with the ultimate goal of revealing new basic biological mechanisms and disease pathophysiology. The small organic molecules he uses are complementary to genetic tools, because such compounds act rapidly and conditionally, can target multiple paralogous proteins simultaneously, and can be readily combined for multi-dimensional manipulations of biochemical networks. His laboratory is particularly interested in understanding cell death mechanisms in mammalian systems, and how they intersect with disease mechanisms in cancer and neurodegeneration. 

More News


Putting Blended Learning to the Test
Electronic media offer valuable tools for learning, but what is the best way to integrate such technologies within the traditional university setting? Brent and Melissa Stockwell recently conducted an innovative, formal trial to find out.
New Algorithm Accurately Predicts Drug Mechanism of Action
DeMAND addresses several key challenges to drug development, holding great potential for improving drugs’ effectiveness, identifying better combination therapies, and avoiding dangerous drug-induced side effects.
Brent Stockwell Receives 2014 Lenfest Distinguished Teaching Award
The Lenfest Award recognizes Columbia University faculty who are both accomplished scholars and provide exceptional instruction, mentorship, and leadership.
High-Throughput Screening and Chemistry Symposium
Learn about the Columbia Genome Center's capabilities in high-throughput screening and synthetic chemistry, and some recent research at Columbia that utilized these tools.