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Nathan Johns and Antonio Gomes

Nathan Johns and Antonio Gomes in the Wang Lab received this year's Distinguished Poster Award.

On June 5, 2015, approximately 150 faculty members, postdocs, and graduate students from the Columbia University Department of Systems Biology gathered at the Tappan Hill Mansion in Tarrytown, New York, for a day filled with illuminating presentations and conversations. The meeting has become a high point of the year for the Department, providing a relaxed environment to socialize and learn about some of the newest methods and discoveries emerging from other laboratories.

Sayantan Bose Receives Best Poster Award

Associate Professor Harmen Bussemaker (left) presents the best poster award to postdoc Sayantan Bose for his efforts to develop a high-throughput platform for performing single-cell RNA-Seq.

On May 30, 2014, the Columbia University Department of Systems Biology and its Center for Multiscale Analysis of Genomic and Cellular Networks (MAGNet) held its annual retreat at Tappan Hill Mansion in Tarrytown, NY. The event provided an overview of some recent work undertaken by Department investigators, and provided a comfortable setting for department members to socialize and exchange ideas about their current research interests.

Department of Systems Biology Symposium

On Thursday, October 17 more than 200 attendees filled the Hammer Health Sciences Center auditorium to celebrate the recent creation of the new Columbia University Department of Systems Biology. The event featured a keynote address by pioneering systems and synthetic biologist James Collins, as well as talks from more than a dozen Department faculty members and other collaborating investigators that spotlighted the wide range of research in computational and systems biology being pursued at Columbia. 

High-throughput screening’s ability to perform thousands of experiments efficiently and under carefully controlled conditions has made it an important tool for basic and translational biological research. At Columbia University, the JP Sulzberger Columbia Genome Center and the Chemical Probe Synthesis Facility provide a flexible platform for researchers interested in applying high-throughput experimentation in their work. On December 17, 2012, the Genome Center hosted a symposium to spotlight its capabilities in high-throughput screening, to explain the important role that synthetic chemistry plays in high-throughput screening, and to describe some recent research projects at Columbia that have utilized these tools.

As High-Throughput Screening Core Scientific Director Charles Karan explained, the Genome Center operates a suite of advanced technologies for automated liquid handling, robotic assay implementation, and high-throughput, high-content microscopy. The Genome Center also offers Columbia University researchers access to several large collections for conducting high-throughput screens. These include the Columbia Cell Line Encyclopedia, which includes 850 cancer cell lines collected from around the world, as well as a chemical diversity library curated by researchers in the Chemical Probe Synthesis Facility. This “tool chest” gives Columbia investigators access to a pre-selected set of compounds that have been predicted to result in the highest quality potential hits. Karan also reported that the Genome Center recently negotiated an arrangement with Sigma Aldrich to give access to the company’s shRNA clones to researchers at Columbia at greatly discounted rates.

The Journal of Cancer Research has just published the proceedings of the American Association of Cancer Research Special Conference on Chemical Systems Biology. Held in Boston on June 27-30, 2012, and co-organized by Andrea Califano (Columbia University), Stuart Schreiber (Broad Institute), and Pamela Silver (Harvard Medical School), the conference spotlighted new opportunities in cancer research that are developing at the interface between chemical biology and systems biology.

November 3, 2008

3rd Annual DREAM Conference

The 3rd Annual DREAM (Dialogue for Reverse Engineering Assessments and Methods) Conference was held at the Broad Institute in Boston from October 29th to November 2nd 2008, jointly with the 5th Annual RECOMB Satellite Conference on Regulatory Genomics and the 4th Annual RECOMB Satellite Conference on Systems Biology. The meeting was organized by the Broad Institute of MIT and Harvard, and the MIT Computer Science and Artificial Intelligence Lab (CSAIL). The meeting brought together computational and experimental scientists in the area of regulatory genomics, to discuss current research directions, latest findings, and establish new collaborations towards a systems-level understanding of gene regulation. The program comprised 16 keynote presentations, 93 oral presentations selected from submitted manuscripts and 1-page abstracts, and 160 posters in four poster sessions. More than 500 participants registered attended the joint meeting, of which the vast majority attended all three meetings. Conference Chairs: Manolis Kellis (MIT), Andrea Califano Columbia University, Gustavo Stolovitzky (IBM). Organizing Commitee: Eleazar Eskin, Nir Friedman, Leroy Hood, Trey Ideker, Douglas Lauffenburger, Satoru Miyano, Eran Segal, Ron Shamir. Partner journal editors: Hillary Sussman, CSHL (Genome Research), Thomas Lemberger, EMBO (Nature MSB), Sorin Istrail, Brown University (Journal of Computational Biology).

Update, January 14, 2009: To read a meeting summary and view multimedia from the event, visit the New York Academy of Sciences eBriefing, Crossing Paths: The RECOMB Regulatory Genomics / Systems Biology / DREAM Conference.

September 19, 2007

2nd Annual DREAM Conference

The 2nd Annual DREAM (Dialogue for Reverse Engineering Assessments and Methods) conference has been announced and will be held December 3 and 4, 2007 at the New York Academy of Sciences in New York, NY.

The conference will feature several speakers including: Tim Gardner, Ravi Iyengar, Fritz Roth, Chris Sander, Ron Shamir, Ilya Shmulevich, Mike Snyder, Peter Sorger, Ioannis Xenarios; as well as a presentation of accepted papers.

Also to be discussed will be the DREAM Challenge, which consists of 5 separate challenges composed of one or more datasets which participants used to generate predictions as to the best possible network from which the data originated. All predictions and results will be disclosed at the conference.

Update, February 28, 2008: For a report on this conference, see the New York Academy of Sciences eBriefing, Educated Guesses: The Second Dialogue on Reverse Engineering Assessment and Methods (DREAM).

The 2007 annual C2B2/MAGNet Center retreat took place on April 6, 2007 at Wave Hill in New York City. Several of the Center's faculty members had the opportunity to present and inform the C2B2/MAGNet community about the ongoing research in their laboratories. 

January 25, 2007

DREAM Conference eBriefing

Meeting notes and presentations from the September 2006 DIMACS Workshop on the Dialogue on Reverse Engineering Assessment Methods (DREAM) are now available as an eBriefing on the New York Academy of Sciences web site.