Harris Wang

Selected Publications

Ricaurte D, Huang Y, Sheth RU, Gelsinger DR, Kaufman A, Wang HH. High-throughput transcriptomics of 409 bacteria-drug pairs reveals drivers of gut microbiota perturbation. Nat Microbiol. 2024 Feb;9(2):561-575. 

Liu L, Huang Y, Wang HH. Fast and efficient template-mediated synthesis of genetic variants. Nat Methods. 2023 Jun;20(6):841-848. 

Huang Y, Sheth RU, Zhao S, Cohen LA, Dabaghi K, Moody T, Sun Y, Ricaurte D, Richardson M, Velez-Cortes F, Blazejewski T, Kaufman A, Ronda C, Wang HH. High-throughput microbial culturomics using automation and machine learning. Nat Biotechnol. 2023 Oct;41(10):1424-1433. 

Trolle J, McBee RM, Kaufman A, Pinglay S, Berger H, German S, Liu L, Shen MJ, Guo X, Martin JA, Pacold ME, Jones DR, Boeke JD, Wang HH. Resurrecting essential amino acid biosynthesis in mammalian cells. Elife. 2022 Sep 27;11:e72847.

McBee RM, Lucht M, Mukhitov N, Richardson M, Srinivasan T, Meng D, Chen H, Kaufman A, Reitman M, Munck C, Schaak D, Voigt C, Wang HH. Engineering living and regenerative fungal-bacterial biocomposite structures. Nat Mater. 2022 Apr;21(4):471-478.

Yim SS, McBee RM, Song AM, Huang Y, Sheth RU, Wang HH. Robust direct digital-to-biological data storage in living cells. Nat Chem Biol. 2021 Mar;17(3):246-253.

Vo PLH, Ronda C, Klompe SE, Chen EE, Acree C, Wang HH, Sternberg SH. CRISPR RNA-guided integrases for high-efficiency, multiplexed bacterial genome engineering. Nat Biotechnol. 2021 Apr;39(4):480-489.

Blazejewski T, Ho HI, Wang HH. Synthetic sequence entanglement augments stability and containment of genetic information in cells. Science. 2019 Aug 9;365(6453):595-598.

Sheth RU, Li M, Jiang W, Sims PA, Leong KW, Wang HH. Spatial metagenomic characterization of microbial biogeography in the gut. Nat Biotechnol. 2019 Aug;37(8):877-883.

Ronda C, Chen SP, Cabral V, Yaung SJ, Wang HH. Metagenomic engineering of the mammalian gut microbiome in situ. Nat Methods. 2019 Feb;16(2):167-170.

Johns NI, Gomes ALC, Yim SS, Yang A, Blazejewski T, Smillie CS, Smith MB, Alm EJ, Kosuri S, Wang HH. Metagenomic mining of regulatory elements enables programmable species-selective gene expression. Nat Methods. 2018 May;15(5):323-329.

Sheth RU, Yim SS, Wu FL, Wang HH. Multiplex recording of cellular events over time on CRISPR biological tape. Science. 2017 Dec 15;358(6369):1457-1461.