Oliver Hobert

Oliver Hobert


Professor, Department of Biochemistry and Molecular Biophysics
Investigator, Howard Hughes Medical Institute


Department of Biochemistry and Molecular Biophysics
Department of Systems Biology


Work: (212) 305-0063

Oliver Hobert is a Professor in the Columbia University Department of Biochemistry and Molecular Biophysics and an Investigator of the Howard Hughes Medical Institute, and holds an Interdisciplinary Faculty position in the Department of Systems Biology. His laboratory studies the molecular mechanisms responsible for generating the remarkable diversity of cell types found in the nervous system. Using C. elegans as a model system, they have revealed the regulatory mechanisms that control terminal neuronal identity and demonstrated that these mechanisms are conserved in chordates. They also used this knowledge to reprogram the identity of heterologous cell types to become specific neuron types. The lab’s other interests include the origins of asymmetrical neuronal differentiation along the left/right axis, the molecular mechanisms of neural system plasticity, and the conservation and evolution of neuronal gene expression programs. His lab has also developed a number of tools to analyze whole genome sequence data.

More News


Stress Wracks Worm Nerves, Leaving Lasting Memories
In a new study, led by Professor Oliver Hobert, PhD, scientists stunted the puberty of male worms by starving them before they underwent sexual maturation. The study, published in Nature, suggested that stress from starvation even days before sexual maturation prevented normal changes in the wiring patterns of key neuronal circuits, which caused adult male worms to act immature.
Oliver Hobert Named Javits Neuroscience Investigator
This prestigious grant supports investigators who have demonstrated exceptional achievement throughout their careers. It will enable the Hobert Lab to investigate sex-based differences in the regulation of neuronal identity.
Three CUMC Faculty Members Receive Interdisciplinary Appointments
Columbia University Medical Center professors Oliver Hobert, Richard Mann, and Rodney Rothstein have joined the Department of Systems Biology to facilitate collaborative research.