Grad Spotlight: Judith Kribelbauer, PhD
Graduating PhD student Judith Kribelbauer aims to understand at a mechanistic level how transcription factors recognize and bind the DNA of a target gene and by doing so, regulate that particular gene’s transcription. The chance to work with researchers spanning areas from biology to chemistry and physics to computer science is what first drew her to Columbia and ultimately to pursuing systems biology.
Building a Better Way to Decode the Genome
Columbia University researchers have developed a computational tool that shines a light on the genome’s most hard-to-translate segments. With this tool in hand, scientists can get closer to understanding how DNA guides everything from growth and development to aging and disease.
Two Faculty Win Vagelos Precision Medicine Pilot Award
Professors Harmen Bussemaker and Tuuli Lappalainen have received an inaugural Roy and Diana Vagelos Precision Medicine Pilot Award. Their research collaboration will bridge quantitative genetics and mechanistic biology to better understand regulatory effects of genetic variants in humans.
New Method for Identifying Genetic Alterations that Modulate Gene Expression
The Bussemaker Lab showed that variants in cofactor genes called cQTLs can change the connectivity between transcription factors and their target genes.
Four Columbia Systems Biology Papers Named among Top Publications
The ISCB/RECOMB Conference on Regulatory and Systems Genomics has announced its top 10 papers of 2014-2015. Four of them involve investigators from the Columbia University Department of Systems Biology.