2010 News

The John Simon Guggenheim Foundation has named Harmen Bussemaker, Associate Professor in Columbia's Department of Biological Sciences, as one of its 2010 Fellows. The award supports a project titled "Deciphering the language of gene expression regulation," in which Dr. Bussemaker will combine methods from biophysics and genetics in order to predict the behavior of gene regulatory networks, and test these predictions using wet lab experiments. Guggenheim Fellows are appointed on the basis of impressive achievement in the past and exceptional promise for future accomplishment. Click here to learn more.

Harmen Bussemaker, Associate Professor in Columbia's Department of Biological Sciences, was one of this year's recipients of the Lenfest Distinguished Columbia Faculty Award. The awards are given annually to faculty of unusual merit across a range of professorial activities — including scholarship, University citizenship, and professional involvement — with a primary emphasis on the instruction and mentoring of undergraduate and graduate students. Click here to learn more.

Transcriptional Network for Mesenchymal Transformation of Brain Tumors

The mesenchymal signature of high-grade gliomas is controlled by six transcription factors. TFs involved in activation of MGES targets are shown in pink, those involved in repression are in purple.

High-grade gliomas, such as glioblastoma, are incurable partly because the tumor cells are widely disseminated throughout the brain. This capacity for invasive growth has been associated with the expression of genes more commonly transcribed in mesenchymal cells. In work published in the journal Nature, Antonio Iavarone, Andrea Califano, and colleagues have identified a small transcription factor network that is responsible for the mesenchymal behavior of glioma cells.