Andrea Califano will receive  $6,909,000 over seven years from the National Cancer Institute for “Predicting Cancer Cell Response to Endogenous and Exogenous Perturbations at the Single Cell Level”. The aims of the project are to create the first generation of genome-and proteome-wide network models that can effectively predict the probabilistic, dynamic response of mammalian cells to small molecule and genetic perturbations, as well as their ability to plastically reprogram  across the relatively small number of molecularly distinct states detected in a specific human malignancy. 

Andrea Califano will receive  $4,893,902 over five years from the National Cancer Institute for “Elucidating and Targeting tumor dependencies and drug resistance determinants at the single cell level”. The aims of the project are to elucidate Master Regulators representing non-oncogene dependencies of molecularly distinct malignant subpopulations coexisting in the same tumor to support novel combination and sequential therapy approaches.